Since 2001, ABC2 has awarded more than 100 grants totaling over $20 million to world-renowned researchers and physician-scientists from 54 institutions. We think strategically about our research investments. Learn more about some of our featured projects by using the filter below to explore our six basic research areas.

Early Immunotherapy for Low-Grade Glioma

Title: Optimizing dendritic cell vaccination for low-grade glioma patients
Investigators: Robert Prins and Linda Liau
Grantee: University of California Los Angeles

Vaccines that train the immune system to recognize and eliminate foreign invaders offer a powerful, personalized weapon in the fight against cancer.  To specialize this weapon for use in brain cancer, Dr. Robert Prins and Dr. Linda Liau (University of California Los Angeles) are developing an anti-tumor vaccine called DCVax.

Repurposing a Skin Medication to Fight Glioma

Title: Pre-Clinical Studies Investigating the Use of Isotretinoin (CRA, ITR) for the Treatment of IDH1 Mutant Glioma Patients
Investigators: Albert Lai, Linda Liau
Grantee: University of California

Targeting Lower-Grade Gliomas

Title: Developing Novel Approaches to Target Glioma
Investigator: Hai Yan
Grantee: Duke University

Mutations in two specific genes, IDH1 and IDH2, are very common in lower-grade and secondary gliomas.  Pinpointing how these mutations are related to brain tumor growth—and finding drugs that counteract their effects—are thus critical goals for treating the many brain cancer patients whose tumors bear these genetic changes.