FOR IMMEDIATE RELEASE
Contacts:
John Reher
650-685-2200
Accelerate Brain Cancer Cure (ABC2)
Justin Jackson
212-213-0006 x 27
Burns McClellan For CaP CURE
Frank C. Mara
408-314-5664
Ingenuity Systems
ABC2, CaP CURE and Ingenuity Systems Kick Off
Program to
Identify Novel Uses for Existing Cancer Drugs
Focus on Intelligently Targeting Highly Active
Pathways in
Brain and Prostate Cancer
Mountain View, California, April 2, 2022 - ABC2, CaP CURE and Ingenuity Systems announced today a partnership that will test existing chemotherapeutic agents against recently discovered gene defects associated with prostate and brain cancer pathways. Leading researchers from Cedars-Sinai Medical Center, University of Michigan, University of California, San Francisco, and University of California, Los Angeles will participate in the program.
"Through a better understanding of how cancer pathways interact, we expect to be able to take existing drugs and in a fraction of the time compared to novel compounds, be able to demonstrate new ways to enhance patient care," stated Dr. David Agus of Cedars-Sinai Medical Center.
The research teams will apply Ingenuity's Pathways Knowledge Base, the world's largest curated, computable model of biological pathways, representing a network of millions of individually modeled interrelationships between genes, proteins, cellular processes, tissues, small molecules, and disease. The scientists will navigate the database using Ingenuity's pathways software, which delivers biologic insights from researchers' experimental data by computationally discerning disease pathways de novo from genomic data.
"We are pleased to be funding research and making it available to the community through this partnership. By leveraging these truly unique assets in combination with world-leading clinical researchers, we believe that we are creating opportunities to quickly bring new treatment paradigms to cancer patients," commented John Reher, executive director of ABC2.
"This project allows us to better understand which genetic pathways are active in these specific cancers and which approved or late-stage, experimental drugs may prove useful in disrupting these pathways," stated Howard Soule, executive vice president and chief science officer of CaP CURE, which helps to support Dr. Agus' research at Cedars-Sinai.
"In concert with these renowned organizations and distinguished researchers, we are forging a new path in the application of systems biology in mitigating the effects of brain and prostate cancers," stated Jake Leschly, president and chief executive officer of Ingenuity.
About ABC2
Dan and Steve Case and their families, along with leading scientists
and entrepreneurs, founded ABC2 in May 2001. ABC2 aims to raise
awareness about brain cancer and help mobilize critical scientific
research through research grants and partnerships. Each year more
than 17,000 people in the United States find out that they have
a primary brain tumor. An additional 100,000 patients are diagnosed
with a brain tumor that has metastasized from another part of the
body. ABC2's mission is to accelerate a cure for brain cancer by
increasing the number of potential therapies discovered and then
rapidly moving them into the clinic to help patients. In order to
accelerate progress in what has been an under-served field of research,
ABC2 provides researchers from all backgrounds with the support
they need to make critical breakthroughs in brain cancer research.
Further information can be found at: www.abc2.org.
About CaP CURE
CaP CURE, the Prostate Cancer Foundation, is the largest non-governmental
source of funding to support research on the prevention, treatment
and cure of prostate cancer. Since its inception in 1993, CaP CURE
has funded more than $120 million to over 1,000 projects in over
100 cancer research centers, and continues to search for sure cures
and controls that will eliminate prostate cancer as a life-threatening
illness for men and their families.
Diagnosed in over 220,000 American men each year - one every 3 minutes - prostate cancer is the most commonly detected non-skin cancer in the United States. Additionally, the disease kills over 30,000 men in the United States each year. Prostate cancer is the second leading cause of cancer death in American men. Further information is available at: www.capcure.org.
About Ingenuity Systems
Ingenuity System's integrated knowledge management solution enables
life science researchers to make Better Decisions Faster
thus increasing the quality and productivity of their research.
The solution leverages a proprietary technology platform and enables
the systematic capture and structure of public and proprietary knowledge
and the delivery of this knowledge through enabling applications.
Ingenuity was founded in 1998 and has 75 employees at its offices
in Silicon Valley, California. For more information, visit us at
www.ingenuity.com.
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