Nanoparticle Drug Delivery in Glioblastoma
Primary Investigator(s): Ana Tari Ashizawa
Full Title: Intravenous Nanoparticle Delivery to Glioblastoma
Name of Institution(s): University of Florida
Original ABC2 Grant Date: March 2015
Initial ABC2 Grant Amount: $875000
One of the things that makes glioblastoma multiforme so difficult to treat is the blood brain barrier, a sort of wall that prevents the vast majority of potential glioblastoma-targeting drugs from ever even reaching the brain. ABC2 is funding groundbreaking new research by Dr. Ana Tari Ashizawa (University of Florida) that may solve this problem. Dr. Ashizawa has developed a new Trojan horse-type nanoparticle capable of slipping drugs past the blood brain barrier and into the brain, where they can directly fight glioblastoma multiforme. By hiding small pieces of genetic material that turn off specific genes inside the nanoparticles, she can target genes known to be important in glioblastoma multiforme. In the project funded by ABC2, Dr. Ashizawa will use both cells and living animals to test whether using the new nanoparticles to target ZEB1, a gene important in glioblastoma multiforme, can turn off the gene and inhibit disease progression. If her project is successful, this new technology could change the paradigm for treatment of patients with glioblastoma multiforme.