Breaking Through Cancer's Shield

For more than a century, researchers were puzzled by the uncanny ability of cancer cells to evade the immune system. They knew cancer cells were grotesquely abnormal and should be killed by white blood cells. In the laboratory, in Petri dishes, white blood cells could go on the attack against cancer cells. Why, then, could cancers survive in the body?

The answer, when it finally came in recent years, arrived with a bonus: a way to thwart a cancer’s strategy. Researchers discovered that cancers wrap themselves in an invisible protective shield. And they learned that they could break into that shield with the right drugs.

When the immune system is free to attack, cancers can shrink and stop growing or even disappear in lucky patients with the best responses. It may not matter which type of cancer a person has. What matters is letting the immune system do its job.

So far, the drugs have been tested and found to help patients with melanoma, kidney and lung cancer. In preliminary studies, they also appear to be effective in breast cancer, ovarian cancer and cancers of the colon, stomach, head and neck, but not the prostate.

It is still early, of course, and questions remain. Why do only some patients respond to the new immunotherapies? Can these responses be predicted? Once beaten back by the immune system, how long do cancers remain at bay?

Still, researchers think they are seeing the start of a new era in cancer medicine.

Click here to read the full New York Times article by Gina Kolata.

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October 21, 2014 09:33 PM
ABC2 CEO Max Wallace chaired the gathering of NCI experts and cancer advocates.
October 15, 2014 12:44 PM
Principal Investigators, based in the state of Florida, are invited to apply. Proposal deadline: December 15, 2014. 
October 14, 2014 12:50 PM
ABC2 funds project between UC San Diego Health System and Regulus Therapeutics Inc.

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